TABLE 1.

Susceptibilities to gemifloxacin and 11 other antimicrobial agents of 400 isolates of N. gonorrhoeae^a

Antimicrobial agent	MIC (μg/ml)			% Susceptible	% Intermediate	% Resistant
	50%	90%	Range
Gemifloxacin	0.003	0.007	0.0005–0.12	NAb
Trovafloxacin	0.007	0.03	0.002–0.25	100
Grepafloxacin	0.003	0.03	0.002–0.25	98.5	1.5
Levofloxacin	0.007	0.003	0.002–0.5	NA
Ofloxacin	0.03	0.03	0.002–1	97.8	2.2
Ciprofloxacin	0.003	0.01	0.001–0.25	93.5	6.5
Norfloxacin	0.003	0.006	0.001–4	NA
Tetracycline	1.0	4.0	0.03–64	13.5	54.2	32.3
Spectinomycin	16.0	16.0	4–32	100
Ceftriaxone	0.003	0.01	0.0005–0.12	100
Cefoxitin	1.0	2.0	0.03–4	94.8	5.2
Penicillin	1.0	64.0	0.003–256	15.0	44.8	40.2

^aThe breakpoints used were those described in NCCLS document M100-S9 (7). The respective concentrations for the susceptible/intermediate/resistant breakpoints were ≤0.25/NA/NA μg/ml for trovafloxacin and ceftriaxone; ≤0.06/0.12 to 0.5/≥1 μg/ml for grepafloxacin and ciprofloxacin, ≤0.25/0.5 to 1/≥2 μg/ml for ofloxacin and tetracycline, ≤32/64/≥128 for spectinomycin, ≤2/4/≥8 μg/ml for cephoxitin, and ≤0.06/0.12 to 1/≥2 μg/ml for penicillin. 

^bNA, the NCCLS breakpoint is not available.