Table 2.
Extraction recovery and matrix effect results of blonanserin and N-desethyl blonanserin in rat plasma (mean ± SD, n = 6).
| Analyte | Concentration (ng·mL−1) | Extraction recovery (%, ± s) | CV (%) | IS-normalized matrix effect (% ± s) | RSD (%) |
|---|---|---|---|---|---|
| Blonanserin | 0.3 | 91.41 ± 6.39 | 6.99 | 65.75 ± 2.98 | 4.53 |
| 30.0 | 87.06 ± 4.56 | 5.23 | 55.73 ± 1.61 | 2.89 | |
| 75.0 | 87.73 ± 2.69 | 3.07 | 53.35 ± 2.36 | 4.43 | |
| N-desethyl blonanserin | 0.3 | 95.39 ± 9.74 | 10.21 | 105.22 ± 2.38 | 2.27 |
| 30.0 | 92.55 ± 2.12 | 2.29 | 102.33 ± 3.60 | 3.52 | |
| 75.0 | 94.10 ± 2.83 | 3.01 | 97.62 ± 2.06 | 2.11 |