Table 2.
Permeation parameters of BZC across Strat-M® artificial membranes from emulsions (EM_BZC), BZC-loaded PLGA nanoparticles (NP_BZC), emulsion incorporated into Poloxamer P407 hydrogels (EM_BZC_P407), BZC-loaded PLGA nanoparticles incorporated into Poloxamer P407 hydrogels (NP_BZC_P407), and BZC-loaded PLGA nanoparticles incorporated into P407 hydrogels associated with 0.5, 0.75, and 1% limonene (NP_BZC_P407_LIM 0.5%, NP_BZC_P407_LIM 0.75%, and NP_BZC_P407_LIM 1%), respectively.
| Nanoformulation | Flux (% cm−2·h-1) | Permeability coefficient (cm·h−1) | Lag time (h) |
|---|---|---|---|
| EM_BZC | 2.7 × 10−4 | 1.13 × 10−7 | 73.3 |
| NP_BZC | 5.2 × 10−4 | 2.20 × 10−7 | 39.1 |
| EM_BZC_P407 | 4.8 × 10−3 | 8.11 × 10−6 | 4.01 |
| NP_BZC_P407 | 5.0 × 10−4 | 8.40 × 10−7 | 43.9 |
| NP_BZC_P407_LIM 0.5% | 3.6 × 10−3 | 6.09 × 10−6 | 14.8 |
| NP_BZC_P407_LIM 0.75% | 2.4 × 10−2 | 4.11 × 10−5 | 1.11 |
| NP_BZC_P407_LIM 1% | 7.3 × 10−3 | 1.21 × 10−5 | 7.53 |