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. 2022 Feb 5;15(4):1063–1073. doi: 10.1111/cts.13230

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© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Plasma concentrations of metoprolol and α‐OH‐metoprolol. Concentrations of metoprolol (left) and α‐OH‐metoprolol (right) by CYP2D6‐inferred phenotype. Data presented as untransformed values. IM, intermediate metabolizer; NM, normal metabolizer; PM, poor metabolizer; UM: ultrarapid metabolizer. Central bar of the box: median; lower bar of the box: first quartile; upper bar of the box: third quartile; diamond: mean; bar below the box: minimum (excluding outliers); bar above the box: maximum (excluding outliers)