TABLE 2.
Association between metoprolol concentrations and CYP2D6 genotype‐inferred phenotypes
| Effect | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Estimate (SE) | p value | Estimate (SE) | p value | Estimate (SE) | p value | Estimate (SE) | p value | Estimate (SE) | p value | |
| CYP2D6 inferred phenotype | −0.506 (0.062) | 1.4 × 10−15 | −0.511 (0.061) | 3.0 × 10−16 | −0.632 (0.051) | 7.0 × 10−33 | −0.634 (0.051) | 1.7 × 10−33 | −0.6306 (0.0503) | 1.5 × 10−33 |
| Age | ‐ | ‐ | 0.017 (0.005) | 0.0005 | 0.015 (0.004) | 0.0001 | 0.012 (0.004) | 0.0025 | 0.0121 (0.0040) | 0.0024 |
| Female sex | ‐ | ‐ | 0.398 (0.094) | 2.3 × 10−5 | 0.392 (0.077) | 4.6 × 10−7 | 0.298 (0.081) | 0.0002 | 0.2855 (0.0803) | 0.00040 |
| Metoprolol dose | ‐ | ‐ | ‐ | ‐ | 0.013 (0.001) | 7.7 × 10−85 | 0.013 (0.001) | 1.2 × 10−87 | 0.0133 (0.0006) | 5.5 × 10−89 |
| Weight | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | −0.008 (0.002) | 0.0002 | −0.0080 (0.0022) | 0.0002 |
| CYP2D6 inhibitors | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | 0.3851 (0.0978) | 0.00009 |
Model 1: crude model; model 2: model adjusted for age and sex; model 3: model adjusted for age, sex, and metoprolol dose; model 4: model adjusted for age, sex, metoprolol dose, and weight; model 5: model adjusted for age, sex, metoprolol dose, weight, and CYP2D6 inhibitors. Intercepts for model 1: 4.821, model 2: 4.012, model 3: 3.191, model 4: 4.003, and model 5: 3.670.
Abbreviation: SE, standard error.