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. 2022 Apr 15;39(5):110770. doi: 10.1016/j.celrep.2022.110770

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© 2022 The Authors

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Potential epitope regions on the spike RBD for effective antibody design

(A) Epitope footprints of four RBD-directed antibodies. The RBD is shown as surface, with mutations within the Omicron RBD highlighted from dark red to light red according to the mutation frequency among different variants so far. Different epitopes are labeled by color.

(B) Surface representation of RBD in complex with 510A5 Fab.

(C–F) Surface models of RBD in complex with four representative antibodies that remain some neutralizing ability against the Omicron variant. RBD is colored in gray, and the four Fab fragments are colored as follows: S309, purple (C); 2-7, yellow (D); S2H97, navy (E); S2X259, green (F).