Fig. 3.

TRPV1 and UCP1 double knockout decreased functional BAT generation and lipolysis. A, B, C Immunoblots of PRDM16, C/EBPβ, and PPARγ (A); PPARδ and HSL (B); and PPARα, SREBP-1c, and C/EBPα (C) in BAT from WT, TRPV1^−/−, UCP1^−/− and TRPV1^−/−/UCP1^−/− mice. Values are presented as the means ± SEM for six mice. *P < 0.05, **P < 0.01vs. WT mice; ^#P < 0.05, ^##P < 0.01 vs. TRPV1^−/− mice; ^∆P < 0.05 vs. UCP1^−/- mice