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. 2022 Mar 21;29(4):376–385. doi: 10.1038/s41594-022-00742-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Upper panels, the two 3D maps colored by local resolution. The dimensions of the structures are labeled. Middle panels, the 0.143 criterion of the gold standard Fourier shell correlation (GSFSC) was used to estimate the average resolutions. Bottom panels, the directional anisotropy of the two maps as quantified by the 3D-FSC server (https://3dfsc.salk.edu/). The sphericity of closed and open state is 0.949 and 0.923, respectively, demonstrating good anisotropic property of both maps.