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. 2022 Apr 14;29(4):403–413. doi: 10.1038/s41594-022-00758-y

Extended Data Fig. 6. Residue contacts of the CENP-N α6-helix with DNA of the DNA-directed nucleosome from simulations containing one (A) and two CENP-N (B).

Extended Data Fig. 6

CENP-N 1 and CENP-N 2 are distinguished by the binding orientation of the α6-helix with the DNA grooves. CENP-N 1 (blue) binds directly into the DNA minor groove while CENP-2 (red) does not. Protein-DNA contacts were defined between the heavy atoms of residues within 4.0 Å of one another. Standard errors were derived using n = 15, where n is the number of statistically independent data points in each window as was determined by calculating the statistical inefficiency.