Table 3.

Treatment mediation

		6 weeks	26 weeks
O-AS avoidance
Threat cognitions
	Total effect	−0·53 (−0·95 to −0·12); p=0·011	−0·43 (−0·85 to −0·02); p=0·042
	Direct effect	−0·38 (−0·79 to 0·03); p=0·066	−0·30 (−0·72 to 0·12); p=0·16
	Indirect effect	−0·14 (−0·27 to −0·02); p=0·022	−0·11 (−0·23 to 0·02); p=0·089
	Proportion mediated*	0·27	0·25
Within-situation defence behaviours
	Total effect	−0·50 (−0·91 to −0·08); p=0·019	−0·40 (−0·81 to 0·02); p=0·063
	Direct effect	−0·35 (−0·76 to 0·05); p=0·087	−0·23 (−0·65 to 0·18); p=0·27
	Indirect effect	−0·15 (−0·29 to −0·02); p=0·027	−0·14 (−0·28 to 0·00); p=0·054
	Proportion mediated*	0·31	0·35
Safety beliefs
	Total effect	−0·57 (−0·99 to −0·15); p=0·0082	−0·50 (−0·92 to −0·08); p=0·021
	Direct effect	−0·50 (−0·92 to −0·08); p=0·019	−0·45 (−0·89 to −0·02); p=0·040
	Indirect effect	−0·04 (−0·12 to 0·04); p=0·32	−0·06 (−0·15 to 0·02); p=0·15
	Proportion mediated*	0·07	0·13
O-AS distress
Threat cognitions
	Total effect	−4·58 (−8·06 to −1·09); p=0·010	−2·89 (−6·40 to 0·61); p=0·11
	Direct effect	−2·54 (−5·86 to 0·79); p=0·14	−1·36 (−4·78 to 2·05); p=0·43
	Indirect effect	−1·62 (−2·96 to −0·27); p=0·018	−1·21 (−2·58 to 0·16); p=0·084
	Proportion mediated*	0·35	0·42
Within-situation defence behaviours
	Total effect	−4·38 (−7·87 to −0·89); p=0·014	−2·60 (−6·11 to 0·91); p=0·15
	Direct effect	−2·17 (−5·42 to 1·07); p=0·19	−0·61 (−3·94 to 2·72); p=0·72
	Indirect effect	−1·81 (−3·38 to −0·24); p=0·024	−1·60 (−3·21 to 0·00); p=0·050
	Proportion mediated*	0·41	0·62
Safety beliefs
	Total effect	−4·89 (−8·49 to −1·29); p=0·0077	−3·14 (−6·75 to 0·47); p=0·088
	Direct effect	−4·23 (−7·80 to −0·67); p=0·020	−2·23 (−5·90 to 1·45); p=0·24
	Indirect effect	−0·45 (−1·31 to 0·42); p=0·31	−0·68 (−1·60 to 0·23); p=0·14
	Proportion mediated*	0·09	0·22

Data are point estimate (95% CI); p value, unless otherwise stated. O-AS=Oxford Agoraphobic Avoidance Scale.

^*Indirect effect divided by total effect.