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. 2022 Apr 13;2(4):100118. doi: 10.1016/j.xgen.2022.100118

Figure 2.

Figure 2

Comparison of polygenic risk scores (PRSs) generated with different methods

The figure shows a comparison of three types of PRSs in UK Biobank: previously published PRSs using a smaller number of variants (“limited-variant PRS”),3,10,17,18 PRSs generated with LDpred, and PRSs generated with PRS-CS. ORs with 95% CI are shown across ancestries for 1 SD increase in the PRS. Detailed effect size comparisons are in Table S3. CAD = coronary artery disease, T2D = type 2 diabetes. Table 1 shows the respective number of cases and controls.