Comparison of polygenic risk scores (PRSs) generated with different methods
The figure shows a comparison of three types of PRSs in UK Biobank: previously published PRSs using a smaller number of variants (“limited-variant PRS”),3,10,17,18 PRSs generated with LDpred, and PRSs generated with PRS-CS. ORs with 95% CI are shown across ancestries for 1 SD increase in the PRS. Detailed effect size comparisons are in Table S3. CAD = coronary artery disease, T2D = type 2 diabetes. Table 1 shows the respective number of cases and controls.