Table 3.
Patient-Reported Hearing Loss (HL) versus Audiometrically-Defined HL at Extended-High Frequencies (10 and 12 kHz), Standard Audiometric Frequencies (0.25-8 kHz), and Both Sets of Frequencies: All Patients
| Patient-reported Hearing Loss |
No audiome trically- defined HLa |
Audiometrically-defined HL at only EHFs (10 or 12 kHz), but none at standard frequencies (0.25-8 kHz) a |
Audiometrically- defined HL at only standard frequencies (0.25-8 kHz) but none at EHFs (10 and 12 kHz) a |
Audiometrically- defined HL at both EHFs (10 or 12 kHz) and standard frequencies (0.25-8 kHz) a |
|||
|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR (95%CI) (vs no HL) |
N (%) | OR (95%CI) (vs no HL) |
N (%) | OR (95%CI) (vs no HL) |
|
| Number b | 259 | 368 | 48 | 592 | |||
| Difficulty hearing c | |||||||
| Not at all | 205 (81.0) | 268 (73.8) | 1.51 (1.02-2.24)f | 35 (72.9) | 1.59 (0.78-3.23) | 312 (53.7) | 3.68 (2.58-5.25)f |
| Any degree | 48 (19.0) | 95 (26.2) | 13 (27.1) | 269 (46.3) | |||
| Problems hearing speech-in-background-noise d | |||||||
| No | 201 (83.8) | 266 (78.0) | 1.45 (0.95-2.23) | 37 (78.7) | 1.39 (0.64-3.03) | 330 (59.0) | 3.58 (2.44-5.24)f |
| Yes | 39 (16.3) | 75 (22.0) | 10 (21.3) | 229 (41.0) | |||
| Tinnitus (ringing in ears) e | |||||||
| Not at all | 174 (68.5) | 247 (68.0) | 1.02 (0.72-1.44) | 31 (66.0) | 1.12 (0.58-2.17) | 277 (47.5) | 2.40 (1.76-3.28)f |
| Any degree | 80 (31.5) | 116 (31.9) | 16 (34.0) | 306 (52.5) | |||
Abbreviations: EHF, extended high frequency; HL, hearing loss; N, number.
Audiometrically-defined HL was based on American Speech-Language-Hearing Association (ASHA) criteria that defined HL as hearing thresholds that exceed 20 dB at any frequency for either ear (Frisina et al. 2016; Le Prell et al. 2011).
Among a total of 1,410 patients, 143 had missing audiometry data at frequencies of both 10 kHz and 12 kHz and are excluded from the table.
Difficulty hearing was assessed with the European Organization for Research and Treatment of Cancer Chemotherapy Induced Peripheral Neuropathy 20-item quality-of-life questionnaire (EORTC-CIPN-20) on the basis of symptoms experienced over the past 4 weeks (Postma et al. 2005). Any degree of difficulty hearing includes participant responses of a little, quite a bit, or very much.
Problems hearing speech-in-background-noise was defined if patients answered “yes” to the following question “Problems hearing words, sounds, or language in crowds?”.
Tinnitus was assessed with the Scale for Chemotherapy-Induced Long-Term Neurotoxicity (SCIN) questionnaire on the basis of symptoms experienced over the past 4 weeks (Oldenburg et al. 2006). Any degree of tinnitus includes participant responses of a little, quite a bit, or very much.
Denotes P values of Pearson Chi-square test with significance at P<0.05.