Table 5.

Common Excipients Among Unique Formulations for Different Molecule Type of Active Pharmaceutical Ingredients

Excipients	Monoclonal Antibody (n = 118)	Excipients	Polypeptide Hormone (n = 109)
Polysorbate 80	61.86%	sodium phosphate	58.72%
Histidine	51.69%	sodium hydroxide	57.80%
Sucrose	38.98%	hydrochloric acid	42.20%
Polysorbate 20	27.97%	metacresol	42.20%
Sodium chloride	25.42%	glycerin	36.70%
Trehalose	16.10%	zinc	36.70%
Sodium phosphate	15.25%	mannitol	33.03%
Citric acid	11.86%	phenol	33.03%
Sodium citrate	11.86%	glycine	22.94%
Sorbitol	10.17%	phosphoric acid	17.43%
Excipients	Cytokine and Growth Factor (n = 83)	Excipients	Enzyme (n = 48)
Sodium phosphate	49.40%	sodium chloride	50.00%
Sodium chloride	43.37%	sodium phosphate	45.83%
Polysorbate 80	38.55%	polysorbate 80	20.83%
Albumin human	26.51%	mannitol	16.67%
Mannitol	20.48%	citric acid	12.50%
Sodium acetate	20.48%	sodium hydroxide	12.50%
Polysorbate 20	18.07%	polysorbate 20	10.42%
Sucrose	16.87%
Citric acid	16.87%
Sodium citrate	15.66%
Excipients	Recombinant Fusion Protein (n = 18)	Excipients	Antibody Conjugate (n = 8)
Sucrose	61.11%	sodium chloride	50.00%
Sodium chloride	44.44%	sucrose	50.00%
Sodium phosphate	44.44%	polysorbate 80	37.50%
Mannitol	33.33%	citric acid	25.00%
Citric acid	27.78%	polysorbate 20	25.00%
Polysorbate 80	27.78%	sodium citrate	25.00%
Sodium citrate	27.78%	sodium phosphate	25.00%
Polysorbate 20	22.22%
Excipients	Toxin (n = 10)	Excipients	Pulmonary Surfactant (n = 3)
Albumin human	100.00%	sodium chloride	100.00%
Sodium chloride	50.00%	colfosceril palmitate	33.33%
Sucrose	30.00%	palmitic acid	33.33%
Lactose	20.00%	sodium bicarbonate	33.33%
Sodium succinate	10.00%	tripalmitin	33.33%