Table 2.
Blood-based significantly differentially expressed genes (p ≤ 0.05) between MDD-S and MDD-NS, the corresponding q value after FDR correction (Q ≤ 0.1 are in bold), and fold change in MDD-S relative to MDD-NS.
| Gene | Mean (Control) | Mean (MDD-NS) | Mean (MDD-S) | p (MDD-S vs. MDD-NS) | q value (MDD-S vs. MDD-NS) | FC (MDD-S vs. MDD-NS) | FC direction |
|---|---|---|---|---|---|---|---|
| PER3 | 6.862 | 6.226 | 7.395 | 0.0009 | 0.0617 | 2.650 | UP |
| MTPAP | 6.824 | 6.628 | 7.377 | 0.002 | 0.030 | 1.801 | UP |
| SLC25A26 | 6.834 | 6.815 | 7.945 | 0.006 | 0.062 | 2.119 | UP |
| CD19 | 6.927 | 6.101 | 7.246 | 0.008 | 0.050 | 1.901 | UP |
| SOX9 | 4.079 | 4.493 | 3.457 | 0.009 | 0.050 | −2.0994 | DOWN |
| GAR1 | 6.209 | 6.227 | 6.734 | 0.009 | 0.130 | 1.436 | UP |
| CREB1 | 9.292 | 9.118 | 9.755 | 0.015 | 0.050 | 1.609 | UP |
| CD6 | 8.542 | 7.553 | 8.984 | 0.020 | 0.050 | 2.346 | UP |
| TERF1 | 8.445 | 8.106 | 8.667 | 0.023 | 0.067 | 1.411 | UP |
| POT1 | 6.624 | 6.886 | 7.403 | 0.034 | 0.051 | 1.484 | UP |
| PER2 | 5.156 | 4.774 | 5.541 | 0.041 | 0.207 | 1.871 | UP |
| GPR37 | 4.513 | 4.600 | 3.996 | 0.043 | 0.067 | −1.571 | DOWN |
| MTHFR | 8.928 | 8.673 | 9.034 | 0.045 | 0.130 | 1.408 | UP |
| NR3C1 | 9.315 | 9.465 | 10.435 | 0.049 | 0.067 | 1.898 | UP |
MDD-S major depressive disorder—suicide, MDD-NS major depressive disorder—non-suicide, FC fold-change, FDR false discovery rate.