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. 2022 Apr 14;11(1):17. doi: 10.1038/s41389-022-00393-8

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Venn diagram for significant upstream (both activated and inhibited) from the single “Core Analysis” using IPA tool based on Proteomics (in green), or Metabolomics (in light red). B Venn Diagram for significant upstream (both activated and inhibited) from integrating “Omics” approaches (in violet) vs the sum of the significant upstream obtained by each single approach (Proteomics + Metabolomics, in yellow).