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. 2022 Apr 14;11(1):17. doi: 10.1038/s41389-022-00393-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Orange and blue shapes represent predicted activation or inhibition, respectively. The predicted relationship between genes may lead to direct activation (orange solid lines) or direct inhibition (blue solid lines). Red and green color indicate genes, proteins, and metabolites increased and decreased in expression, respectively, while the numbers represent the measurements of their expression. A1 shows the proteins and metabolites of the loaded dataset involved in the activation of the upstream regulator Interferon alpha. A2 shows the mechanistic network, theoretically reconstructed that underlies the activation of the upstream Interferon alpha. B1 shows the proteins and metabolites of the loaded dataset involved in the activation of the upstream regulator Fibroblast growth factor 7 (FGF7). B2 shows the mechanistic network, theoretically reconstructed that underlies the activation of the upstream FGF7. C1 shows the proteins and metabolites of the loaded dataset involved in the activation of the upstream regulator Insulin (INS). C2 shows the mechanistic network, theoretically reconstructed that underlies the activation of the upstream INS. D shows the proteins and metabolites of the loaded dataset involved in the down-regulation of the upstream regulator Histone deacetylase 5 (HDAC5).