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. 2022 Apr 1;13:870094. doi: 10.3389/fimmu.2022.870094

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Copyright © 2022 Castro, Carvajal, Jara, Aguilera, Heathcote, Barrera, Aliaga-Tobar, Maracaja-Coutinho, Urzúa, Quest, González, Molina, Hermoso and González

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression profile of miRNAs found in LSG from SS-patients and sicca controls using NGS. (A) Heat map of differentially expressed miRNAs in LSG from sicca controls (C) and SS-patients with low (L) and high (H) focus score (FS). The rows of the heat map represent miRNAs, while the columns represent different LSG samples. A zoom to the hsa-miR-181d-5p is displayed. (B-D) Volcano plots of miRNAs down-regulated (blue dots), up-regulated (red dots) or stable (grey dots) found in LSG from SS-patients with low (L) FS, compared to sicca controls (B); high (H) FS, compared to sicca controls (C); and low (L) FS, compared to high (H) FS (D). The filter used was Log2FC=|2| and p-value ≤ 0.05.