FIGURE 6.

Tubulin isoforms are differentially regulated at the mRNA level through isoform-specific transcription and/or autoregulation during cardiac hypertrophy. Relative log₂fold-change of mRNA counts of αβ-tubulin isoforms that are predominantly regulated through (A) autoregulation, or (B) transcription (n = 4 h: 6, 4 days: Ctrl:7, PE:7, Iso:6); * represents p-value from Welch-corrected two-tailed two-sample t-test on non-log data <0.025 (Bonferroni-corrected for two comparisons), ** represents p < 0.01, and *** represents p < 0.001. Scatter-plots of relative log₂fold-change of intron on x-axis and exon on y-axis at (C) 4-h and (D) 4-days timepoints; whiskers represent ± 1SEM.