TABLE 3.
Results of treatment of viridans group streptococcus experimental endocarditis
| Species group | Treatment | No. of animals/ no. sterile | Log10 CFU/g of vegetation
|
|
|---|---|---|---|---|
| Median | Range (25th–75th percentile) | |||
| S. sanguis | None | 7/0 | 11.0 | 10.5–11.2 |
| Trovafloxacin | 15/0 | 10.7 | 10.3–11.0 | |
| Vancomycin | 12/0 | 7.7 | 6.0–8.4 | |
| Penicillin | 12/0 | 7.2 | 6.5–9.5 | |
| S. mitis | None | 6/0 | 10.1 | 9.7–10.3 |
| Trovafloxacin | 5/4 | 4.64a | 4.4–5.1 | |
| Vancomycin | 5/3 | 5.31a | 4.7–5.6 | |
| Penicillin | 6/4 | 4.0a | 4.3–5.6 | |
a
Sterile cultures were assigned a value equal to the lower limit of detection.