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. 2022 Apr 1;13:840692. doi: 10.3389/fphar.2022.840692

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Copyright © 2022 Nussbaumer-Pröll, Eberl, Kurdina, Schmidt and Zeitlinger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time kill curves (TKC) with meropenem of E. coli ATCC-25923 (A), (B), (C) and of the average CFU/mL of five E. coli isolates (D), (E), (F) are shown over 24 h with standard deviation. In (A), (B), and (C) the standard deviations are very small and overlaid by symbols. The circular symbols represent the growth controls, filled show the centrifuged, and empty depict the native GC. The concentration of the MIC of the tested strains is given as a star symbol. Empty arrows indicate antibiotic addition and filled arrows indicate antibiotic removal.