TABLE 3.

Hydrolysis modification of D-ring lactam of Matrine.

Name of matrine derivative	Basic structure of derivatives	R1 substituent structure	R2 substituent structure	Structure of matrine derivatives	Pharmacol-ogical activity	Refrence
Butyl 12-benzyl matrine					Anti tumor	Chao et al. (2013)
12-matrine thiomorphamide					Anti tumor	Chao et al. (2013)
12-N-Benzenesulfonyl Matrine Butane					Antivirus	Li et al. (2017a)
12-N-4-Methoxybenzyl Sophora Ethanol					Antivirus	Li et al. (2020)
12-N-dodecyl matrine butyl ester					Antivirus	Fu and TangSLi (2014)