TABLE 5.

C-14 position modification of Matrine.

Name of matrine derivative	Basic structure of derivatives	R Substituent structure	Structure of matrine derivatives	Pharmacological activity	Refrence
N-benzyl-2-pyrromethene matrine				Anti tumor	Zhang et al. (2018a)
N-3,5 dimethoxybenzyl-2-pyrromethene matrine				Anti tumor	Zhang et al. (2018a)
N- 3-chlorobenzyl-3-6-methoxyindole methylene matrine				Anti tumor	Zhang et al. (2018a)
14–3,4,5-trimethoxybenzylidene matrine				Anti tumor	Wei et al. (2013)
Compound 2				Anti tumor	Wu et al. (2016)
14-[2-(6-bromo) naphthalene hydroxymethenyl] matrine				Anti tumor	Yang (2015)