TABLE 6.

C-13 position modification of Matrine.

Name of matrine derivative	R Substituent structure	Structure of matrine derivatives	Pharmacological activity	Refrence
13 - (N-methylene) amino-18 thiomatrine			Anti-inflammatory	Guo et al. (2011)
13-(N-methyl)-amino-18-thiomatrine			Anti-inflammatory	Zou (2018)
13-α-methoxy matrine			Sterilization	Han et al. (2012)
Compound 3			Anti tumor	Cui et al. (2015)
Compound 4			Anti tumor	Cui et al. (2015)
Compound 5			Anti tumor	Cui et al. (2015)
13- (N-4-tert-butylbenzyl) hydroxyethylamin-e matrine			Anti tumor	Dai et al. (2019b)