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. 2022 Apr 1;13:775246. doi: 10.3389/fgene.2022.775246

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Copyright © 2022 de Araújo, Menezes, Aguiar and Souza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plot illustrating ACE1 rs4646994 (Alu 287 pb) association with COVID-19 severity (severe × others). Significant allelic and genotypic effects were observed. Case and control definitions are presented in Table 2. (A) D-allele model. D-allele was associated with increased risk of COVID-19 severity. (B) D recessive model. D/D genotype carriers showed increased odds to manifest severe COVID-19 compared with D/I and I/I carriers combined (C) I recessive model. I/I genotype carriers showed decreased odds to present severe COVID-19 compared with D/I and D/D carriers combined.