TABLE 1.

Summarization of possible manifestations of pathophysiological mechanisms responsible for occurrence of COVID-19-related neurological problems in relation to acute and post-acute phase of Sars-CoV-2 infection.

Possible pathophysiological mechanisms responsible for occurrence of COVID-19-related neurological problems	Possible manifestation of the particular pathophysiological mechanism in ACUTE Sars-CoV-2 infection	Possible manifestation of the particular pathophysiological mechanism in POST- ACUTE Sars-CoV-2 infection
1. Direct damage of Sars-CoV-2 to neural tissue	Yes	Yes
2. Indirect damage of Sars-CoV-2 to neural tissue	Yes	Yes
3. Long-term recovery of damaged neural tissues	It probably does not manifest in the early phases of the acute infection. Rather, it is likely to start to manifest in its later phases (sub-acute phase)	Yes
4. COVID-19-related dysfunction of extraneural tissue	Yes	Yes
5. Psychological factors	Yes	Yes
6. Mutual co-occurrence and interference between multiple post-COVID-19 neurological symptoms	Yes	Yes