Response to radioiodine therapy in a 62-year-old man with PDTC. Panel A shows several ‘hot spots’ in neck and chest, diffuse distribution of 131I in both lungs by post-therapeutic whole-body scan on day 3 after the initial administration of 7.4 GBq of 131I. SPECT/CT scan shows 131I-avid mediastinal lymph node measuring 34 mm × 28 mm (B, upper, SPECT image; middle, CT image; lower, SPECT/CT fusion image). Panel C shows similar findings to the initial post-therapeutic 131I whole body scan on day 3 after the second administration of 7.4 GBq. Panel D shows the shrinkage of the mediastinal lymph node measuring 29 mm × 25 mm (upper, SPECT image; middle, CT image; lower, SPECT/CT fusion image). Arrow head, mediastinal lymph node.