. 2022 Feb 23;11(3):e210554. doi: 10.1530/EC-21-0554
This work is licensed under a Table 1.
Summary of reported studies of vitamin D and specific autoimmune disease. Publications for individual autoimmune diseases reporting effects of (i) serum vitamin D-deficiency; (ii) genetic variation in vitamin D status determined by Mendelian randomisation; (iii) SNPs for specific components of the vitamin D transport/metabolism/signalling system.
| Autoimmune disorder | Vitamin D deficiency | Mendelian randomisation | SNPs |
|---|---|---|---|
| Rheumatoid arthritis | Reviewed in Harrison et al. 2020 (49) | Bae and Lee 2018 (83) Viatte et al. 2014 (84) |
VDRsystematic review Bagheri-Hosseinabadi et al. 2020 (85) DBP/GCYan et al. 2012 (86) |
| Sjögren’s syndrome | Systematic review Kuo et al. 2020 (87) Li et al. 2019 (88) Erten et al. 2015 (89) |
||
| Systemic lupus erythematosus | Arshad et al. 2021 (90) Reviewed in Kamen et al. 2006 (91) Reviewed in Dall’Ara et al. 2018 (92) |
Bae and Lee 2018 (83) |
VDRChen et al. 2017 (93) CYP27B1Fakhfakh et al. 2021 (94) |
| Inflammatory bowel disease (IBD) | Systematic Review Del Pinto et al. 2015 (95) Systematic Review Gubatan et al. 2019 (96) |
Lund-Nielsen et al. 2018 (97) |
VDRGisbert-Ferrándiz et al. 2018 (98) DBP/GCEloranta et al. 2011 (99) |
| Multiple sclerosis (MS) | Reviewed in Sintzel et al. 2018 (100) | Mokry et al. 2015 (78) Rhead et al. 2016 (79) Harroud et al. 2018 (101) |
CYP27B1Sundqvist et al. 2010 (102); Orton et al. 2008 (103) CYP2R1Scazzone et al. 2018 (104) DBP/GCAgliardi et al. 2017 (105) VDRReviewed in Scazzone et al. 2021(106) |
| Type 1 diabetes mellitus | Meta-analysis Hou et al. 2021 (107) Meta-analysis Feng et al. 2015 (108) |
Manousaki et al. 2021 (109) |
VDRNejentsev et al. 2004 (110) CYP2R1, DBP/GC, CYP24A1Almeida et al. 2020 (111) |
| Guillain-Barre syndrome Chronic inflammatory demyelinating polyneuropathy |
Elf et al. 2014 (112) | ||
| Psoriasis | Fu et al. 2021 (113) Pitukweerakul et al. 2019 (114) Reviewed in Hambly and Kirby 2017 (115) |
VDRLiu et al. 2020 (116) | |
| Autoimmune thyroid disease | Ke et al. 2017 (117) Xu et al. 2015 (118) Wang et al. 2015 (119) |
VDRZhou et al. 2021 (120) VDRMeng et al. 2015 (121) CYP27B1Jennings et al. 2005 (122) |
|
| Myasthenia gravis | Justo et al. 2021 (123) Kang et al. 2018 (124) Askmark et al. 2012 (125) |
VDRHan et al. 2021 (126) | |
| Vasculitis | Korkmaz et al. 2021 (127) Yoon et al. 2020 (128) Systematic Review Khabbazi et al. (2019) (129) |
Zhong et al. 2021 (130) |