. 2022 Feb 17;186(5):R65–R77. doi: 10.1530/EJE-21-1171
This work is licensed under a Table 1.
Expression pattern of proteins involved in local TH action in immune cells.
| Cell type | THT | DIO | THR | NCS | TSH receptor | Reference |
|---|---|---|---|---|---|---|
| Neutrophil | MCT8, MCT10 (h) | DIO3, DIO1 (h) | THRa (h) | Yes | (5, 69, 70) | |
| Macrophage | MCT8, MCT10, LAT2, OATP4a1 | DIO2 | THRa >> THRb | Yes | (54, 55, 56, 57, 58) | |
| Monocyte | DIO2 (h) | Yes | Yes | (54, 81, 108) | ||
| Dendritic cell | MCT10 >> LAT2 | DIO3 >> DIO2 | THRa, THRb | Yes | (6, 65, 110) | |
| Natural killer cell | MCT8 (h), MCT10 (h) | THRa (h), THRb (h) | Yes | (87, 108) | ||
| T cell | THRa, THRb | Yes | Yes | (97, 98, 109, 110) | ||
| B cell | THRa, THRb | Yes | Yes | (104, 108) |
If not indicated data are from mice.
DIO, deiodinase; h, human; NCS, noncanonical signaling; THR, TH receptor; THT, TH transporter; TSH, thyroid stimulating hormone.