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. 2022 Apr 1;10:762129. doi: 10.3389/fcell.2022.762129

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Copyright © 2022 Song, Zhang, Liu, Hu, Feng, Shi, Zhang, Wang, Xie, Zhang, Zhao, Cao, Li and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global topological features of pathway crosstalk networks. Here, we show topological features of one network (GSE1145) and others are shown in Supplementary Figures. (A) Degree distributions of network. (B) Pathways with high degree encompassed more genes than others. (C) Pathways with high degree occupied more ceRNA pairs than others. (D) Pathways with high degree had more crosstalk activities than others. We replaced the p value = 0 with p value = 0.0001. (E) Degree distributions of four pathway databases. (F) Betweenness distributions of four pathway databases.