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. 2022 Apr 1;12:865121. doi: 10.3389/fonc.2022.865121

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Copyright © 2022 Li, Dong, Wu, Wang, Jin, Chen, Huang, Huang and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4 mRNA and CD8 mRNA expression level is related to the sensitivity of tumor cells to NAC drugs. (A–C) CD4 mRNA expression level is significantly and positively correlated with the sensitivity of tumor cells to (A) cyclophosphamide (r = 0.81, p < 0.0001), (B) cisplatin (r = 0.30, p < 0.05), and (C) carboplatin (r = 0.47, p < 0.001). (D) CD8 mRNA expression level is significantly and positively correlated with the sensitivity of tumor cells to cyclophosphamide (r = 0.41, p < 0.01). (E, F) CD8 mRNA expression level is not significantly correlated with the sensitivity of tumor cells to (E) cisplatin (r = 0.18, p = 0.18) and (F) carboplatin (r = 0.18, p = 0.17).