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. 2022 Apr 1;13:838171. doi: 10.3389/fphar.2022.838171

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Copyright © 2022 Dong, Du, Cai, Lin, Chen, Still, Yao, Coppes, Pan, Zhang, Gao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTPRO is downregulated in lapatinib-resistant ERBB2-positive breast cancer cells. (A) The mRNA level of PTPRO in the lapatinib resistant ERBB2-positive breast cancer cells, SKBR3-lapR and BT474-lapR, compared with their parental cells, SKBR3-P and BT474-P. The dataset GSE38376 and GSE16179 were get from GEO (https://www.ncbi.nlm.nih.gov/geo/). (B) Inhibition ratio analysis of SKBR3-lapR and SKBR3-P (upper panel), BT474-lapR and BT474-P (bottom panel) was evaluated by MTT assay after treatment with lapatinib. (C) Colony formation abilities of SKBR3-lapR and SKBR3-P (left panel), BT474-lapR and BT474-P (right panel) were evaluated after treatment with lapatinib, and the number of colonies was counted (bottom panel). (D) The PTPRO protein expression derived from lapatinib resistant ERBB2-positive cells and their parental cells were assessed by western blot analysis. Data were shown as the means of three independent experiments or representative data. Error bars indicate SEM. *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t-test or one-way ANOVA with post hoc intergroup comparisons, where appropriate.