图 3.

SARS-CoV-2 S蛋白的重组区

Recombination regions in the Spike protein of SARS-CoV-2. To initiate a CoV infection, the S protein encoded by the S gene needs to be cleaved into the S1 and S2 subunits for receptor binding and membrane fusion. RC3-7 are recombination regions in the genomes of betacoronavirus subgroup B. Three recombination regions (RC3, RC4 and RC5) are localized in the N-terminal domain (NTD) of the S1 subunit, while two other recombination regions (RC6 and RC7) are localized in the receptor binding domain (RBD) of the S1 subunit. A: Only mutations in RBD regions across SARS-CoV-2 lineages are represented, based on the data from 2, 678, 671 SARS-CoV-2 genomes downloaded from outbreak. info on August 8th, 2021. B: The elements used to represent the structure of the S protein were originally used in a previous study ^[10]. RBD (in blue color) and NTD (in blue color) are two domains of the S1 subunit.