TABLE 1.
Antimycobacterial activities of six fluoroquinolones against 250 clinical isolates of M. tuberculosis
| Organism group (no. of strains) and drug | MIC (μg/ml)
|
|||
|---|---|---|---|---|
| Range | For 50% of strains | For 90% of strains | Geometric mean | |
| S-MTB (206) | ||||
| Ciprofloxacin | ≤0.125–16 | 1 | 1 | 0.744 |
| Ofloxacin | ≤0.125–16 | 1 | 1 | 0.842 |
| Levofloxacin | ≤0.125–8 | 0.5 | 1 | 0.549 |
| Grepafloxacin | 0.25–32 | 1 | 1 | 0.782 |
| Trovafloxacin | 4–>128 | 32 | 64 | 29.917 |
| Gemifloxacin | ≤0.125–64 | 4 | 8 | 4.878 |
| R-MTB (44) | ||||
| Ciprofloxacin | 0.5–8 | 1 | 2 | 0.882 |
| Ofloxacin | 0.5–16 | 1 | 2 | 1.171 |
| Levofloxacin | ≤0.125–8 | 0.5 | 1 | 0.741 |
| Grepafloxacin | 0.5–32 | 1 | 2 | 1.189 |
| Trovafloxacin | 4–>128 | 32 | 128 | 34.623 |
| Gemifloxacin | 2–64 | 8 | 8 | 6.417 |
| All isolates (250) | ||||
| Ciprofloxacin | ≤0.125–16 | 1 | 1 | 0.766 |
| Ofloxacin | ≤0.125–16 | 1 | 2 | 0.893 |
| Levofloxacin | ≤0.125–8 | 0.5 | 1 | 0.579 |
| Grepafloxacin | 0.25–32 | 1 | 1 | 0.842 |
| Trovafloxacin | 4–>128 | 32 | 64 | 30.697 |
| Gemifloxacin | ≤0.125–64 | 4 | 8 | 5.120 |