Figure 2.

Postpartum T cell tolerance is overridden in the presence of pregnancy-sensitized B cells and fetus-specific antibodies. (A–C) Loss of pregnancy-induced T cell tolerance and F1 graft rejection is driven by cognate interactions between pregnancy-primed T and (A) pregnancy-primed B cells but not (B) naive B cells, or (C) with antigen-presenting dendritic cells (DC) activated by donor antigen (Ag) opsonized with pregnancy-primed F1-specific antibodies. The signals overriding T cell tolerance requires definition. PP, postpartum.