Table 1.
Retrospective clinical studies assessing the correlation between pregnancy and allograft outcome
| Author | No. of transplants | Outcome |
|---|---|---|
| Terasaki et al. (1995) | Husband-to-mother: n = 368 | Comparable allograft survival between spousal donor and unrelated living donor. Pregnancy is a risk factor for loss of allograft |
| Child-to-mother: n = 1,411 | ||
| Mahanty et al. (2001) | Offspring-to-mother: n = 874 | Fetal tolerance did not translate to a superior allograft survival from offspring donors. Multiple pregnancy trended towards poor allograft survival |
| Unrelated living donor to mother: n = 310 | ||
| Cohen et al. (2003) | Offspring-to-parent: n = 3,370 | Comparable death censored 5-yr allograft survival in offspring-to-parent compared to unrelated living donor |
| Unrelated living donor: n = 8,351 | ||
| Deceased donor: n = 44,792 | ||
| Miles et al. (2008) | Offspring to mother: n = 3,124 | Comparable and poor allograft survival in offspring-to-parent and parent-to-offspring transplants |
| Parent to offspring: n = 6,076 | ||
| Ghafari (2008) | Offspring-to-mother: n = 12 | Unrelated living donor allografts survival was significantly higher compared to offspring and husband donor allografts |
| Husband-to-mother: n = 9 | ||
| Unrelated living donor: n = 150 | ||
| Choi et al. (2012) | Offspring-to-mother: n = 49 | Comparable 5- and 10-yr kidney graft survival between offspring-to-mother and offspring-to-father transplant. Mother-to-child had worse outcome |
| Parent-to-offspring: n = 146 | ||
| Redfield et al. (2016) | Highly sensitized: n = 7,145 | Increased graft loss by 23% among women with a history of pregnancy and transfusion compared to non-sensitized |
| Non-sensitized: n = 100,147 | ||
| Cohen et al. (2018) | Offspring-to-mother: n = 1,332 | Comparable allograft survival between offspring and unrelated living donor transplant to mother |
| Unrelated living donor: n = 1,435 | ||
| Dagan et al. (2020) | Offspring-to-mother: n = 148 | Offspring donor allograft survival lower compared to unrelated living donor |
| Unrelated living donor: n = 93 | Male offspring donor resulted in poorer survival compared to female offspring donor | |
| Senn et al. (2021) | Husband-to-mother: n = 25 | Poor allograft survival among mothers who received allograft from spouse compared to unrelated living donor or deceased donor |
| Unrelated living donor: n = 52 | ||
| Deceased donor: n = 120 |