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. 2022 Mar;10(6):273. doi: 10.21037/atm-22-867

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Different tumor immune cell infiltration status in HNSCC patients. (A,B) Typical high-resolution images of mIHC from two random samples. Different colours represent different immune cell subpopulations. white, CD8; cyan, PanCK; purple, CD56; green, CD68; red, HLA-DR. (C) Heatmap of the infiltration of immune cells in the parenchyma and stroma. (D-I) The box diagram shows the infiltration of different immune cell subtypes in the parenchyma and stroma. HNSCC, head and neck squamous cell carcinoma; mIHC, multiplexed immunohistochemistry; M, macrophage; NK cell, natural killer cells.