Table 3. Univariate and multivariate Cox analysis of HNSCC clinicopathological factors.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |||
| Age | 510 | 1.018 (1.005–1.031) | 0.005 | 1.020 (1.007–1.033) | 0.003 | |
| Stage | 510 | |||||
| I | 27 | Reference | ||||
| II | 81 | 2.157 (0.760–6.120) | 0.148 | 2.141 (0.754–6.078) | 0.153 | |
| III | 94 | 2.442 (0.866–6.889) | 0.092 | 2.652 (0.940–7.481) | 0.065 | |
| IV | 308 | 3.405 (1.260–9.197) | 0.016 | 3.498 (1.294–9.459) | 0.014 | |
| Grade | 510 | |||||
| G2 | 297 | Reference | ||||
| G3 | 123 | 0.828 (0.599–1.145) | 0.254 | |||
| G1 | 61 | 0.613 (0.390–0.964) | 0.034 | |||
| GX | 22 | 0.600 (0.279–1.290) | 0.191 | |||
| G4 | 7 | 0.000 (0.000–Inf) | 0.992 | |||
| B cell | 510 | 0.000 (0.000–0.003) | 0.005 | 0.000 (0.000–0.017) | 0.010 | |
| Cancer-associated fibroblast | 510 | 0.841 (0.358–1.973) | 0.690 | |||
| T cell CD4 | 510 | 2.688 (0.155–46.673) | 0.497 | |||
| T cell CD8 | 510 | 0.000 (0.000–0.011) | 0.005 | 0.000 (0.000–0.366) | 0.032 | |
| Endothelial cell | 510 | 0.000 (0.000–72.063) | 0.209 | |||
| Macrophage | 510 | 154.583 (0.000–84,002,295.704) | 0.454 | |||
| NK cell | 510 | 0.051 (0.000–932,749,993,272.6) | 0.848 | |||
Univariate variables with P<0.05 were chosen for the multivariate analysis. COX, proportional hazards model; HNSCC, head and neck squamous cell carcinoma; CI, confidence interval; NK cell, natural killer cells.