Figure 4.

JPTGY regulates biomarkers of BAT and WAT through mTORC1 signaling in vivo. Mice were administered an HFD to induce obesity and were then treated with the JPTGY and/or the mTOR agonist MHY. Protein levels of BAT biomarkers, WAT biomarkers (A), and mTORC1/SREBP (B) in abdominal adipose tissue were detected by western blotting assay. The relative protein levels were calculated and are presented in histograms. *P<0.05 vs. control; ^#P<0.05 vs. obesity; ^&P<0.05 vs. control and JPTGY; ^P<0.05 vs. MHY. JPTGY, Jian Pi Tiao Gan Yin; HFD, high-fat diet, BAT, brown adipose tissue; WAT, white adipose tissue; mTORC1, mechanistic target of rapamycin complex 1; mTOR, mechanistic target of rapamycin; SREBP, sterol regulatory element binding protein.