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. 2022 Mar;10(6):282. doi: 10.21037/atm-22-762

Table 2. The common targets of the active ingredients of Cordyceps sinensis and depression.

Disease Compound Common targets
Depression MOL008998 MAOB, DLG1, CREBBP, AR, HSD11B1, DDC, ESR2, CAT, SOD2, USH1C, F2, HSD17B4, CD8A, BCL2A1, GDI1, NPC2, MMP2, ALAD, SMS, RBP4
MOL000953 CREBBP, AR, HSD11B1, ACHE, CAT, EGF, SOD2, F2, HSD17B4, CD8A, GDI1, MOG, NPC2, RBP4, ACTA1, HEXA
MOL000358 MAOB, CREBBP, AR, ACHE, USP8, EGF, SOD2, F2, GDI1, NPC2, RBP4, HEXA
MOL001645 GAD1, DLG1, S100B, CREBBP, EP300, AR, ACHE, DDC, ZEB2, ESR2, CAT, SOD2, USH1C, F2, HSD17B4, INSR, CD8A, BCL2A1, CDH11, GDI1, MOG, SIN3A, NPC2, ALAD, RBP4, ACTA1
MOL011169 DLG1, CREBBP, AR, ACHE, ESR2, CAT, SPD2, HSD17B4, MANB1, CDH11, GDI1, MOG, NPC2, RBP4
MOL001439 GAD1, MAOB, DLG1, S100B, CREBBP, AR, DDC, ZEB2, ESR2, CAT, SOD2, USH1C, F2, HSD17B4, CD8A, GDI1, MOG, SIN3A, NPC2, HBB, MMP2, ALAD, RBP4, ACTA1, ANXA5
MOL008999 ESR1, GAD1, S100B, CREBBP, EP300, AR, ACHE, DDC, ESR2, SYNGAP1, CAT, SOD2, F2, HSD17B4, VDR, CD8A, HMOX1, GDI1, MOG, NPC2, HBB, CNP, RBP4, ACTA1