TABLE 2.

Inhibitory effect of AZT and indinavir, combined with sulfadiazine or pyrimethamine

Drug and concn (μg/ml)	OD value (103) at indicated drug concn (μg/ml)a
	AZT					Indinavir
	0	1	5	25	100	0	1	5	25	100
Sulfadiazine
0	630 ± 106	642 ± 131	626 ± 97	648 ± 78	376 ± 103	734 ± 86	762 ± 97	692 ± 71	654 ± 107	287 ± 85
0.02	512 ± 91	523 ± 103	554 ± 97	537 ± 81	309 ± 77	605 ± 111	666 ± 55	637 ± 122	624 ± 114	254 ± 91
0.2	209 ± 51	172 ± 40	201 ± 45	169 ± 45	135 ± 27§	188 ± 92	284 ± 122	400 ± 116	249 ± 107	62 ± 31§
2	31 ± 26	27 ± 15	30 ± 20	27 ± 20	27 ± 19	28 ± 18	42 ± 30	36 ± 16	26 ± 20	31 ± 21
Pyrimethamine
0	932 ± 104	1,013 ± 75	989 ± 109	898 ± 145	743 ± 83	697 ± 143	813 ± 120	837 ± 84	837 ± 90	330 ± 32
0.01	959 ± 104	1,062 ± 105	927 ± 106	908 ± 112	703 ± 82	643 ± 136	755 ± 110	800 ± 164	791 ± 122	339 ± 56
0.05	706 ± 84	702 ± 52	666 ± 97	679 ± 57	587 ± 65§	552 ± 38	603 ± 86	745 ± 112	795 ± 103	250 ± 51§
0.25	100 ± 36	107 ± 65	92 ± 50	92 ± 19	81 ± 22	80 ± 40	79 ± 16	76 ± 11	78 ± 29	84 ± 29

^aEach value represents the results from 8 to 12 replicate wells from 2 or 3 replicate plates. P values were calculated for the interaction effect. §, additive but not synergistic effect (P > 0.05).