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. 2022 Mar;10(6):364. doi: 10.21037/atm-22-994

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Probability sensitivity analysis in whole cohort. (A) Scatterplot of the cost-effectiveness plane. (B) The cost-effectiveness acceptability curve. Results of the probabilistic sensitivity analysis based on 10000 Monte Carlo simulations, which involved sampling cost and probabilities variables of the model from distributions imposed on variables to explore the uncertainty of cost-effectiveness between PER + AEDs and AEDs at different willingness-to-pay thresholds. AEDs refer to the maintenance of conventional therapy. PER, perampanel; AED, antiepileptic drug; QALY, quality-adjusted life years.