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. 2022 Mar;10(6):304. doi: 10.21037/atm-22-556

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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DBH-AS1 increases the sensitivity of PC cells to gemcitabine. (A) qPCR analysis of DBH-AS1 levels in PC cells via following gemcitabine (0, 5, and 10 nM) treatment. (B) Representative growth curves for Canpan-2/gemcitabine and Canpan-2 cells. (C) qPCR analysis of DBH-AS1 levels in Canpan-2/gemcitabine and Canpan-2 cells. (D) qPCR analysis of DBH-AS1 levels in Canpan-2/gemcitabine following LV-NC or LV-DBH-AS1 treatment. (E) Representative growth curves for gemcitabine-treated Canpan-2/gemcitabine cells treated with LV-NC and LV-DBH-AS1, or Canpan-2 cells treated with shControl or shDBH-AS1. IC50, half-maximal inhibitory concentration. (A,C,D) t-test; (B,E) variance test. Data are means ± SEM from triplicate experiments, *, P<0.05. PC, pancreatic cancer; qPCR, quantitative polymerase chain reaction; sh, short hairpin.