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. 2022 Mar;10(6):304. doi: 10.21037/atm-22-556

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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DBH-AS1 knockdown enhances PC cell growth via the downregulation of USP44. (A,B) CCK-8 assay of PC cells treated with shControl or shDBH-AS1 and LV-USP44 or LV-NC. (C,D) Canpan-2 cells following stable shControl or shDBH-AS1 transfection and LV-USP44 or LV-NC treatment subcutaneously implanted in nude mice (n=5/group). LV-DBH-AS1 treatment was associated with slower PC tumor growth in these animals. Scale bar: 1cm. (A,B,D) t-test. Data are means ± SEM from triplicate experiments, *, P<0.05. PC, pancreatic cancer; CCK-8, cell-counting kit 8; sh, short hairpin.