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. 2022 Mar;10(6):334. doi: 10.21037/atm-22-520

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Elevated DNA methylation may contribute to increased expression of ZDHHC12 in glioma. (A) The DNA methylation level of ZDHHC12 significantly decreased in different histological types of glioma tissue (CGGA datasets). (B) The DNA methylation level of ZDHHC12 significantly decreased in glioma tissues with a higher WHO grade (CGGA datasets). (C) The DNA methylation level of ZDHHC12 significantly decreased in IDH wild-type glioma tissues (CGGA datasets). (D) Kaplan-Merrier survival plot of ZDHHC12 methylation level in primary glioma (CGGA datasets). (E) Low amplification was observed in glioma samples (TCGA dataset). (F) Significant negative correlation was observed between ZDHHC12 methylation and expression level (TCGA dataset). ZDHHC, zinc finger DHHC-type palmitoyltransferase; CGGA, Chinese Glioma Genome Atlas; TCGA, the Cancer Genome Atlas, WHO, World Health Organization; IDH, isocitrate dehydrogenase.