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. 2022 Mar;10(6):350. doi: 10.21037/atm-22-115

Figure 7.

Figure 7

MiR-122 antagomir combined with sevoflurane further reduced IR-induced liver damage. The rats were randomly divided into the IR group, the IR + miR-122 antagomir group, and the IR + miR-122 antagomir + Sevo group. Liver injury was induced in the rats in the IR group through ischemia/reperfusion. The mice in the IR + miR-122 antagomir group were pretreated with miR-122 antagomir and then liver injury was induced through ischemia/reperfusion. The mice in the IR + miR-122 antagomir + Sevo group were pretreated with miR-122 antagomir, then liver injury was induced through ischemia/reperfusion, and then the rats inhaled 2% sevoflurane. (A) H&E staining of liver tissue sections (magnification: ×200, scale bar =100 mm; ×400, scale bar =50 mm). (B) The Suzuki score of livers. (C) The levels of AST, ALT, and LDH in the serum of rats. Quantified values were mean ± standard deviation of at least three independent experiments. ▲, P<0.05, ▲▲, P<0.01 vs. the IR group;★, P<0.05, ★★, P<0.01 vs. the IR + miR-122 antagomir group. +, this group rats were treated with indicated agent; −, this groups did not receive this indicated treatment. IR, ischemia-reperfusion; H&E, hematoxylin and eosin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase.