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. 2022 Apr 1;13:842555. doi: 10.3389/fimmu.2022.842555

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Copyright © 2022 Mordoh, Aris, Carri, Bravo, Podaza, Pardo, Cueto, Barrio and Mordoh

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical update of VACCIMEL-immunized patients. (A) DMFS follow-up of the CASVAC-0401 study patients as of 10/05/2021 (p = 0.035, Wilcoxon test). Arms: VACCIMEL (black) (n = 19); IFNα2b (red) (n = 11). (B) DMFS Kaplan–Meier and Cox-regression comparison of adjuvant treatments for CM patients. Treatments: Combined VACCIMEL-immunized patients from Phase I and II studies (black) (9, 10); dabrafenib (yellow) (28); ipilimumab (light blue) (27); nivolumab (blue) (5); pembrolizumab (red) (6). (C) Forest plot of hazard ratio comparison of DMFS of different treatments versus VACCIMEL.