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Patient #5 case report. (A) Time course of the disease and treatments received. ITM biopsies analyzed are indicated with a green box. (B–E) Pictures of ITM on patient’s right leg: (B) relapse after ending vaccination protocol; (C) progression before nivolumab; (D) response after nivolumab 240 mg every 14 days for 1 year; (E) relapse after 4 years nivolumab, showing multiple red amelanotic 1- to 3-mm-wide tumors.
