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. 2022 Apr 1;13:842555. doi: 10.3389/fimmu.2022.842555

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Copyright © 2022 Mordoh, Aris, Carri, Bravo, Podaza, Pardo, Cueto, Barrio and Mordoh

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Patient #5 immune response to common melanoma antigens. (A) T-cell response induced by VACCIMEL to HLA-A0201-restricted peptides from shared melanoma-associated antigens detected by IFN-γ ELISPOT. Pre: blood extracted at the selection process; Post 1, Post 2, and Post 3: blood extracted 6, 12, and 25 months after protocol start. (B) Quantification of the spots normalized to 10⁵ PBMC (right panel). (C) PMEL, tyrosinase (TYR), SOX-2 and MAGE B2 antigens abundance in VACCIMEL as determined by RNA-Seq and normalized in TPM.