TABLE 1.

Effect of the C-8-methoxy fluoroquinolone PD161148 against clinical isolates of M. tuberculosis

Isolate no.	MIC (μg/ml)	MPC (μg/ml)a	IS6110 typeb	Genotype groupc	Sourced	Antibiotic resistancee
TN1626	0.1	1.0	W	1	N.Y.	I, S, R, Em, K
TN7811	0.1	1.0	Unique	3	Russia	S, K
TN7804	0.1	1.0	W148	1	Russia	I, S, R, Et, K
TN6515	0.07	1.5	W4	1	N.J.	None
TN7791	0.1	1.5	Unique	2	Russia	I
TN7829	0.1	2.3	Unique	3	Russia	None
TN7834	0.1	2.3	Unique	3	Russia	None
TN5704	0.2	2.3	Unique	1	N.J.	I
TN5355	0.2	2.3	Unique	3	N.J.	None
TN5410	0.2	2.3	Unique	2	N.J.	None
TN3541	0.2	2.3	DV	1	N.Y.	I, R, Em
TN1865	0.3	3.0f	H	2	N.Y.	None
TN2156	0.3	3.5	CO	2	N.Y.	None
TN5702	0.4	4.0f	Unique	1	N.J.	I

^aThe MPC was determined as the PD161148 concentration required to prevent the recovery of resistant mutants when >2 × 10⁹ CFU was applied to each of five agar plates. Each experiment was performed twice, with results similar to those shown obtained each time. 

^bIS6110 DNA pattern as described previously (11). 

^cGenotype group as described previously (16). 

^dFrom the Public Health Research Institute Tuberculosis Center collection. Abbreviations: N.Y., New York; N.J., New Jersey. 

^eIsolates were resistant to the indicated antibiotics: I, isoniazid; S, streptomycin; R, rifampin; Em, ethambutol; K, kanamycin; Et, ethionamide. 

^fDetermined by extrapolation from linear plots as in inset to Fig. 2.