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Synthesis of lopinavir (31). Reagents and conditions: (a) N,N‐carbonyldiimidazole, ethyl acetate; yield: 82.7%; (b) ammonium formate, palladium on charcoal, methanol; yield: 100%; (c) l‐pyroglutamic acid (PGA), acetone, DMF; yield: 72.4%; (d) 2,6‐dimethylphenoxyaceticacid, thionyl chloride, dichloromethane; yield: 85.7%
